Central Macedonia is one of the thirteen peripheries of Greece, consisting of the central part of the region of Macedonia. It is divided into the prefectures of Chalkidiki, Imathia, Kilkis, Pella, Pieria, Serres, and Thessaloniki. The population is around 2 million, the second biggest in Greece.

The building of the Central Macedonia Periphery is located in Taki Ekonomidi Avenue, in Eastern Thessaloniki. Although geographically part of central Macedonia, Mount Athos is not administratively part of the periphery, or any other periphery, but an autonomous self-governing state under the sovereignty of Greece.